Humberto G. Ortiz Zuazaga

Office: A-153
Extension: 7430, 88363
Website: http://ccom.uprrp.edu/~humberto/
Email: humberto.ortiz@upr.edu

  • Ph.D. in Computer Science and Engineering. University of Puerto Rico Mayagüez Campus (2008)
  • B.Sc. (Hons.) in Computer Science. University of Cincinnati (1994)

Research Areas

Bioinformatics: analysis of functional genomic data, microarrays, high–throughput sequencing. Cyberinfrastructure: high performance and grid computing, advanced networking.


Publications

    Articles

      Published
      • Roberto Arce Corretjer, Humberto Ortiz–Zuazaga (2013). Majority logic decoding: a discrete method for detecting differential expression in RNA–Seq data. BIOCOMP’13: The 14th International Conference on Bioinformatics and Computational Biology
      • Joseph Morris Pastrana, Brenda G Nieves, CB Torres Nieves, Emma Fernández–Repollet, Humberto Ortiz–Zuazaga, Jose G. Conde (2012). An e–Ticket System for Tracking Research Support Services. 13th RCMI International Research Symposium in San Juan, Puerto Rico, December 10–13, 2012
      • Leah J. Campbell, Edna C. Suárez–Castillo, Humberto Ortiz–Zuazaga, Dunja Knapp, Elly M. Tanaka, Craig M. Crews (2011). Gene Expression Profile of the Regeneration Epithelium during Axolotl Limb Regeneration. Developmental Dynamics
        http://dx.doi.org/10.1002/dvdy.22669
      • Nancy Arroyo Gonzalez , Adrinel Vázquez , Humberto G. Ortiz Zuazaga, Arup Sen , Hugo Luna Olvera, Sandra Peña de Ortiz and N. S. Govind (2009). Genome–wide expression profiling of the osmoadaptation response of Debaryomyces hansenii. Yeast, 111-124
        http://dx.doi.org/10.1002/yea.1656
      • Lorena Saavedra–Rodríguez, Humberto Ortiz–Zuazaga, Lissette Andrés, Karen Rodríguez, Fernando Ramírez, Adrinel Vázquez, and Sandra Peña de Ortiz (2009). Identification of flap–structure specific endonuclease 1 as a factor involved in long–term memory formation of aversive learning. Journal of Neuroscience, 18, 5726-5737
        http://dx.doi.org/10.1523/JNEUROSCI.4033-08.2009
      • Pablo A Ortiz–Pineda, Francisco J Ramírez–Gómez, Judit Pérez–Ortiz, Sebastián González-Díaz, Francisco Santiago-De Jesús, Josue Hernández-Pasos, Carmencita Rojas-Cartagena, Edna C Suárez-Castillo, Karen Tossas-Robles, Ana T Méndez-Merced, José L Roig-López, Cristina Del Valle-Avila, Humberto Ortiz-Zuazaga and José E García-Arrarás (2009). Gene expression profiling of intestinal regeneration in the sea cucumber. BMC Genomics, 262
        http://dx.doi.org/10.1186/1471-2164-10-262
      • Humberto Ortiz Zuazaga, Tim Tully, Oscar Moreno (2008). Majority logic decoding for probe–level microarray data. Proceedings of BIOCOMP'08 – The 2008 International Conference on Bioinformatics & Computationa
      • Filipa Godoy–Vitorino, Ruth E. Ley, Zhan Gao, Zhiheng Pei, Humberto Ortiz–Zuazaga, Luis R. Pericchi, Maria A. Garcia-Amado, Fabian Michelangeli, Martin J. Blaser, Jeffrey I. Gordon, Maria G. Dominguez-Bello (2008). Bacterial Community in the Crop of the Hoatzin, a Neotropical Folivorous Flying Bird. Applied and Environmental Microbiology, 19, 5905-5912
        http://dx.doi.org/10.1128/AEM.00574-08
      • Rojas–Cartagena C, Ortiz–Pineda PA, Ramirez–Gomez F, Suarez–Castillo EC, Matos-Cruz V, Rodriguez C, Ortiz-Zuazaga H, Garcia-Arraras JE (2007). Distinct profiles of expressed sequence tags (ESTs) during intestinal regeneration in the sea cucumber Holothuria glaberrima. Physiol Genomics, 203-215
        http://dx.doi.org/10.1152/physiolgenomics.00228.2006
      • Humberto Ortiz–Zuazaga, Sandra Peña de Ortiz, Oscar Moreno de Ayala (2007). Error Correction and Clustering Gene Expression Data Using Majority Logic Decoding. Proceedings of The 2007 International Conference on Bioinformatics and Computational Biology (BIOCOM
      • Ortiz–Zuazaga, H., Aviño–Diaz, M. A., Laubenbacher, R., Moreno, O (2003). Finite fields are better Booleans. Seventh Annual Conference on Computational Molecular Biology (RECOMB 2001), Germany
      • Y. Robles, P. E. Vivas, H. G. Ortiz–Zuazaga, Y. Felix, S. Peña de Ortiz (2003). Hippocampal gene expression profiling in spatial learning.. Neurobiology of Learning and Memory, 1, 80-95
        http://dx.doi.org/10.1152/physiolgenomics.00228.2006
      • H.G. Ortiz–Zuazaga, Y. Robles, R. Chiesa, S. Peña de Ortiz (2001). Analysis of Learning–Related Changes in Gene Expression Using Nylon Membrane cDNA Microarrays. Fifth Annual International Conference on Computational Molecular Biology (RECOMB 2001). Montreal, Qu
      • H. Ortiz–Zuazaga and R. Plaetke (1997). Screening genetic markers with the maximum weighted clique method. Genome Mapping and Sequencing. Cold Spring Harbor, NY
      • S.L. Naylor, R. Plaetke, H. Ortiz–Zuazaga, P. O'Connell, B. Reus, X. He, R. Linn, S. Wood, and R.J. Leach (1997). Construction of Framework and Radiation Hybrid Maps of Chromosomes 3 and 8. Genome Mapping and Sequencing. Cold Spring Harbor, NY
      • H. Ortiz–Zuazaga and R. Plaetke (1997). Screening genetic markers with the maximum weighted clique method. First International Conference on Computational Molecular Biology. Albuquerque, NM
      • H. Ortiz–Zuazaga and R. Plaetke (1996). TkMap: a bioTk program for drawing genetic or radiation hybrid maps. American Society for Human Genetics 46th Annual Meeting
      • R. Plaetke, B.E. Reus, R. Linn, R. Rodriguez, H. Ortiz–Zuazaga, D. Buley, P. O'Connell, S.L. Naylor, and R.J. Leach (1996). A radiation hybrid map of human chromosome 3 consisting of 153 markers. American Society for Human Genetics 46th Annual Meeting, San Francisco, CA
      • G. Schachtel, H. Ortiz–Zuazaga, and R. Plaetke (1996). BPE: an environment for meiotic breakpoint mapping. American Society for Human Genetics 46th Annual Meeting, San Francisco, CA
      • F. S. Annexstein, J. V. Franco, H. Ortiz–Zuazaga, and R. P. Swaminathan (1994). Distributed implementations of algorithms for satisfiability problems. Ohio Aerospace Institute / Ohio Supercomputer Center / NASA
      • G. Sfyris, N. Sperelakis, H. Ortiz–Zuazaga, J. B. Picone, and E. Stepp. (1993). Length constant as a function of intercellular coupling of a cardiac muscle strand analog with applied longitudinal current.. Mathl. Comput. Modelling, 1, 131-139
      • N. Sperelakis, H. Ortiz–Zuazaga, J. E. Mann, Jr. (1992). Voltage interaction between sarcolemma and junctional SR membrane.. Mathl. Comput. Modelling, 11, 101-115
      • N. Sperelakis, H. Ortiz–Zuazaga, and J. B. Picone (1991). Fast conduction in the electric field model for propagation in cardiac muscle.. Innov. et Tech. en Biol. et Med., 4, 404-414


Professional Activities

    Awards and Recognitions

    • William McIntire Memorial Scholarship, University of Cincinnati (1993)

    Talks

    • Comparing empirical Bayes and majority logic decoding methods for detecting differential expression in public RNA–Seq data from Drosophila melanogaster, XXVIII Inter University Seminar on Mathematical Sciences Research (SIDIM). Universidad Metropolitana, San Juan, Puerto Rico (2013)
    • Microarray analysis of oral cancer samples, An Introduction to Microarray Data Analysis workshop, Puerto Rico Comprehensive Cancer Center (2011)
    • Research Networking in Puerto Rico, Caribbean Telecommunications Union Caribbean Information Communication Technology Roadshow (2011)
    • Network Tuning at the UPR for Transmission of Multispectral Images in Support of Relief Efforts in Haiti, Internet2 Member Meeting, Arlington, Virginia (2010)
    • Network Tuning for Rapid Transmission of Multispectral Images for Relief Efforts in Haiti, Caribbean Regional Interest Group, Internet2 Member Meeting, Arlington, Virginia (2010)
    • Bioinformatics: principles and applications, Centro de Educacion Virtual in the Encarnacion Valdez Library of the Pontificial Catholic University of Puerto Rico (2010)

    Workshops Given

    • AECC Python Workshop, University of Puerto Rico, Rio Piedras Campus (2012)

    Synergistic Activities

    • Director of the UPR HPCf, including the Internet2 GigaPOP, the Bioinformatics Resource Center (BiRC), the Center for Numerical Supercomputing and Computational Nanoscience Resource Center (CNaRC).
    • Member of the External Advisory Committee for the NSF–STEM Alan Turing Scholarship awarded to students in Mathematics and Computer Science, University of Puerto Rico, Rio Piedras Campus.
    • Key Function Leader for Biomedical Informatics in the Puerto Rico Clinical and Translational Research Consortium. Provides biomedical informatics support to UPR Medical Sciences Campus, Universidad Central del Caribe, and Ponce School of Medicine and Health Sciences researchers.


Grants

    Submitted

    • Puerto Rico Center for Gene and Gene Expression Studies (GenExPRC), National Institutes of Health
      Role: Senior Personnel
      Funds: $11,052,382

    Current

    • CC-NIE Networking Infrastructure: Perimeter Network to Expedite the Transmission of Science Project (PR NETS), NSF
      Role: Co-PI (Co-Principal Investigator)
      Start date: October 1, 2013 | End date: September 30, 2015
      Funds: $499,667
    • Nanotechnology from basic science to emerging applications: Institute for functional nanomaterials, NSF EPSCoR
      Role: Senior Personnel
      Start date: October 1, 2010 | End date: September 30, 2015
      Funds: $24,000,000
    • Collaborative Research: Cyberinfrastructure–enabled Computational Nanoscience for Energy Technologies, NSF EPSCoR
      Role: Co-PI (Co-Principal Investigator)
      Start date: October 1, 2010 | End date: September 30, 2013
      Funds: $2,697,799
    • Advancing Competitive Biomedical Research in Puerto Rico, NIH NCRR
      Role: Senior Personnel
      Start date: August 1, 2009 | End date: July 31, 2014
      Funds: $18,050,756

    Completed

    • Puerto Rico Clinical and Translational Research Consortium, NIH NCRR
      Role: Senior Personnel
      Start date: September 17, 2010 | End date: June 30, 2013
      Funds: $16,398,579
    • MRI–R2: Acquisition of genomic and bioinformatic technology to promote research at the University of Puerto Rico, NSF
      Role: Co-PI (Co-Principal Investigator)
      Start date: July 1, 2010 | End date: June 30, 2013
      Funds: $637,664
    • Networking research resources across America, NIH NCRR
      Role: Senior Personnel
      Start date: September 25, 2009 | End date: August 31, 2011
      Funds: $7,499,857